Differential Bio‐Optoelectronic Gating of Semiconducting Carbon Nanotubes by Varying the Covalent Attachment Residue of a Green Fluorescent Protein

Integrating photoactive proteins with synthetic nanomaterials holds great promise in developing optoelectronic devices whereby light, captured by a antenna protein, is converted to modulated electrical response. The protein–nanomaterial interface critical defining properties; successful integration of bionanohybrids requires control over protein attachment site and detailed understanding its impact on device performance. Here, the first single-walled carbon nanotube (SWCNT) bio-optoelectronic transistor enabled site-specific direct interfacing green fluorescent (GFP) via genetically encoded phenyl azide photochemistry reported. behavior individual semiconducting SWCNTs depends residue coupling provides basis design eco-friendly phototransistors memory. Attachment at one GFP proximal chromophore produces wavelength-specific phototransistor. bio-transistor can be switched off less than 38 s responsivity up 7 × 103 A W−1 470 nm. second distal generates memory that show rapid reproducible conductivity switching 15-fold modulation restored application gate voltage. Therefore, proteins, especially GFP, realized as key material for novel single-molecule electronic photonic devices.